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Focal nodular hyperplasia and hepatocellular adenomas: What is new in 2013?
Elisa Palladino1, Daniele Sommacale2, Renaud Siboni1, Christine Hoeffel3, Christian Lechner1, Tullio Piardi2, Reza Kianmanesh2
1Department of General and Digestive Surgery, Chalons-en-Champagne Hospital, France.
2Department of General, Digestive and Endocrine Surgery, Reims University Hospital, France.
3Department of Radiology, Reims University Hospital, France.

Article ID: 100016IJHPDEP2014
doi:10.5348/ijhpd-2014-16-RA-4

Address correspondence to:
Elisa Palladino
MD, Department of General and Digestive Surgery
Chalons-en-Champagne Hospital, 51
rue du Commandant Derrien - BP 80501, 51005 Chalons en Champagne
France
Phone: +33 (0)326696032
Fax: +33 (0)326696095
Email: palladinoelisa@hotmail.com

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How to cite this article
Palladino E, Sommacale D, Siboni R, Hoeffel C, Lechner C, Piardi T, Kianmanesh R. Focal nodular hyperplasia and hepatocellular adenomas: What is new in 2013? Int J Hepatobiliary Pancreat Dis 2014;4:15–25.


Abstract
Introduction: The history of benign liver cell tumors, namely, focal nodular hyperplasia (FNH), and hepatocellular adenoma (HCA), has recently progressed thanks to molecular biology and imaging studies that made it possible a new classification used in European, American and East countries.
Case Report: A review was performed of the numerous published articles, with focus on the management and clinical outcome of benign liver cell tumors is an attempt to promote more standardized guidelines.
Conclusion: The discovery of genetic drivers of HCA has refined our knowledge of the life history of HCA from risk factors of malignant transformation. The clinical management of FNH and HCA have changed in the recent years. This will have an impact on the management of these lesions including surveillance.

Keywords: Focal nodular hyperplasia, Benign liver cell tumors (BLCT), Liver lesions, Hepatocellular adenoma

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Author Contributions
Elisa Palladino – Substantial contriutions to conception and designs, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Daniele Sommacale – Substantial contriutions to conception and designs, Acquisition of data, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published
Renaud Siboni – Substantial contriutions to conception and designs, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Christine Hoeffel – Substantial contriutions to conception and designs, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Christian Lechner – Substantial contriutions to conception and designs, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Tullio Piardi – Substantial contriutions to conception and designs, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Reza Kianmanesh – Substantial contriutions to conception and designs, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2014 Elisa Palladino et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



About The Authors

Elisa Palladino is Resident at Department of General and Digestive Surgery of Chalons-en-Champagne Hospital, France. Her area of interest include liver surgery, gastrointestinal surgery, minimally invasive abdominal surgery. She has published research papers in national and international academic journals.



Daniele Sommacale is Professor at Department of General and Digestive Surgery, University of Reims, School of Medecine, France. His area of interest include hepatobiliary surgery and liver transplantation. He has published research papers in national and international academic journals and authored books.



Renaud Siboni is Resident at Department of Surgery, University of Reims, France. His area of interest include general surgery.



Christine Hoeffel (MD, PhD) She is Professor of Radiology at the University hospital of Reims, France. She has published or co-published over 100 papers, mainly focused on abdominal imaging and magnetic resonance imaging.



Christian Lechner is Chief Resident at Department of General and Digestive Surgery of Chalons-en- Champagne Hospital, France. His area of interest include gastrointestinal surgery, minimally invasive abdominal surgery.



Tullio Piardi is Resident at Department of General and Digestive Surgery, University of Reims, School of Medecine, France. His area of interest include liver and pancreatic surgery, gastrointestinal surgery. He has published research papers in national and international academic journals.



Reza Kianmanesh is a Professor at Department of General and Digestive Surgery, University of Reims, School of Medecine, France. His area of interest include hepatobiliary and pancreatic surgery, liver transplantation, gastrointestinal surgery. He has published research papers in national and international academic journals and authored books.