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Case Report
A unique presentation of peliosis hepatis: A case report and comprehensive review of the literature
1 University of South Carolina School of Medicine Greenville, Greenville, SC, USA
2 Department of Radiology, Prisma Health Upstate, Greenville, SC, USA
3 Pathology Associates, 8 Memorial Medical Ct., Greenville, SC, USA
Address correspondence to:
Christine Marie-Gilligan Schammel
PhD, Director, Clinical Research, Department of Pathology, Prisma Health Upstate, SC, USA; Pathology Associates, 8 Memorial Medical Ct., Greenville, SC 29605,
USA
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Article ID: 100103Z04AT2023
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How to cite this article
Teshon A, Walker C, Schammel DP, Schammel CMG, Devane AM. A unique presentation of peliosis hepatis: A case report and comprehensive review of the literature. Int J Hepatobiliary Pancreat Dis 2023;13(1):16–25.ABSTRACT
Introduction: Peliosis hepatis (PH) is a rare benign vascular condition characterized by dilatation of hepatic sinusoids with occasional involvement of other organs. While associated with chronic immunosuppression, anabolic steroid use, oral contraceptive (OCP) use, human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), and infection with Bartonella, most PH patients are asymptomatic and, thus, identified incidentally. Compromised liver function is sometimes evident through laboratory tests; however, mortality results from cyst rupture and hemorrhage spontaneously or during surgical procedures.
Case Report: We report a case of PH identified in a 33-year-old Black female radiologically evaluated for abnormal liver function tests. Computed tomography (CT) revealed enhancement of >100 lesions throughout both liver lobes; a CT-guided biopsy revealed mild macrovesicular steatosis and marked sinusoidal dilation, consistent with peliosis hepatis.
Conclusion: We also present a comprehensive literature review describing the associated conditions, pathology, diagnostic methods, and treatment options for PH patients.
Keywords: Benign vascular liver condition, Dilation of sinusoidal liver spaces, Peliosis hepatis
SUPPORTING INFORMATION
Author Contributions
Alex Teshon - Acquisition of data, Interpretation of data, Drafting the article, Final approval of the version to be published
Crystal Walker - Substantial contributions to conception and design, Acquisition of data, Drafting the article, Final approval of the version to be published
David P Schammel - Acquisition of data, Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Christine Marie-Gilligan Schammel - Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
A Michael Devane - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2023 Alex Teshon et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
