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Case Report
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| Self limiting postoperative hyperbilirubinemia after hepatectomy in a patient of Intrahepatic cholangiocarcinoma with Dubin–Johnson syndrome: A case report | ||||||
| Nagarkar RV1, Roy S.2, Tondare A.A.3, Kulkarni N.C.4, Suryavanshi S.P.5, Paleja N.P.6 | ||||||
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1MS (Gen Surg), DNB, MRCS (Edin), MNAMS, BSS (UK), Head of Dept., Surgical Oncology, Curie Manavata Cancer Center, Nashik, Maharashtra, India.
2MS (Gen Surgery), Senior Consultant, Surgical Oncology, Curie Manavata Cancer Center, Nashik, Maharashtra, India. 3DNB (Gen Surgery), Surgery Registrar and Fellow Breast Surgery, Surgical Oncology, Curie Manavata Cancer Center, Nashik, Maharashtra, India. 4MD (Anaesthesiaology), Head of Dept., Dept of Anaesthsiology, Curie Manavata Cancer Center, Nashik, Maharashtra, India. 5BHMS, PGDCR, Managing Director, Manavata Clinical Research Institute, Curie Manavata Cancer Center, Nashik, Maharashtra, India. 6BAMS, PGDCR, Director, Manavata Clinical Research Institute, Curie Manavata Cancer Center, Nashik, Maharashtra, India. | ||||||
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| Nagarkar RV, Roy S, Tondare AA, Kulkarni NC, Suryavanshi SP, Paleja NP. Self limiting postoperative hyperbilirubinemia after hepatectomy in a patient of Intrahepatic cholangiocarcinoma with Dubin–Johnson syndrome: A case report. Int J Hepatobiliary Pancreat Dis 2015;5:56–60. |
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Abstract
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Introduction:
Dubin Johnson syndrome (DJS) is a benign disease of bilirubin metabolism, which causes only jaundice since birth, but there are no other symptoms or signs. DJS is so rare that its exact incidence in Indian population is not known. Incidence of intrahepatic cholangiocarcinoma (ICC) is around 3.3%. Occurrence of DJS simultaneous with hepatobiliary malignancies has been reported four times previously, predominantly in the Japanese population. There are no reports of such cases from Indian population. Also, in the reported cases the functional reserves of liver were complicated by presence of pre-existing cirrhosis of liver. There is no data suggesting the influence of concomitant DJS in a patient with liver cancers.
Case Report: We present a case of 63-year-old (Indian) male who was diagnosed with DJS in early thirties and on routine health checkup was found to have space occupying lesion in liver. It turned out to be Intra hepatic cholangiocarcinoma on further workup. We state our experience in postoperative management, hyperbilirubinemia as well as further management of disease. Conclusion: Although it is not possible to predict the exact dynamics of DJS over ICC or vice versa, the outcomes of hepatectomy in such scenario are benign, self limiting and do not require any specific treatment. | |
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Keywords:
Dubin–Johnson syndrome, Intrahepatic Cholangiocarcinoma, Hepatectomy, Postoperative hyperbilirubinemia
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Author Contributions
Nagarkar R.V. – Substantial contributions to conception and design, Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Roy S. – Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published Tondare A.A. – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published Kulkarni N.C.– Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published Suryavanshi S.P.– Acquisition of data, Analysis of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Paleja N.P. – Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2015 Nagarkar R.V. et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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