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Original Article
 
Clinicopathological significance of fatty acid synthase expression in pancreatic ductal carcinoma
Hiroshi Maekawa1, Tomoaki Ito2, Hajime Orita1, Koichi Sato3, Ryo Wada4
1Associate professor, department of surgery, Juntendo university school of medicine Shizuoka hospital, Izu-no-kuni city, Shizuoka, Japan.
2Assistant professor, department of surgery, Juntendo university school of medicine Shizuoka hospital, Izu-no-kuni city, Shizuoka, Japan.
3Professor, department of surgery, Juntendo university school of medicine Shizuoka hospital, Izu-no-kuni city, Shizuoka, Japan.
4Professor, department of pathology, Juntendo university school of medicine Shizuoka hospital, Izu-no-kuni city, Shizuoka, Japan.

Article ID: 100011IJHPDHM2013
doi:10.5348/ijhpd-2013-11-OA-2

Address correspondence to:
Hiroshi Maekawa
1129 Nagaoka, Izu-no-kuni
Shizuoka
Japan 410-2295
Phone: 81 55.948.3111
Fax: 81 55.946.0514
Email: hmaekawa0201@gmail.com

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How to cite this article:
Maekawa H, Ito T, Orita H, Sato K, Wada R. Clinicopathological significance of fatty acid synthase expression in pancreatic ductal carcinoma. International Journal of Hepatobiliary and Pancreatic Diseases 2013;3:10–16.


Abstract
Introduction: Fatty Acid Synthase (FAS) expression is increased in various cancers and it contributes to tumor cellular activities. In clinical practice, pancreatic ductal carcinoma is regarded as a cancer with poor prognosis.
Aims: To investigated FAS expression in pancreatic ductal carcinoma (PDC) and compare with clinic-pathological features.
Methods: We studied 38 patients who had resection for PDC in our hospital. We compared FAS staining with clinico-pathological features, including Ki-67 and p53 staining.
Results: Using our criteria, out of 38 cases, 15 cases were considered FAS positive. FAS positivity correlated with Ki-67 positivity (p = 0.001), but there was no significant relationship between FAS expression and p53 staining (p = 0.224). FAS positive cases showed higher rate of lymph node metastases (p = 0.0038). FAS expression was related to differentiation of adenocarcinoma (p = 0.0347). Clinically, overall survival rate of FAS positive cases was lower than that of FAS negative cases (p = 0.0068).
Conclusions: FAS expression may be related to lymph node metastases and clinical behavior in pancreatic ductal carcinoma.

Key Words: Pancreatic cancer, Fatty acid synthase, Ki-67, Immunohistochemistry, Prognosis

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Author Contributions:
Hiroshi Maekawa - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Tomoaki Ito - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Hajime Orita - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Koichi Sato - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Ryo Wada - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Guarantor of submission:
The corresponding author is the guarantor of submission.
Source of support:
None
Conflict of interest:
Authors declare no conflict of interest.
Copyright:
© Hiroshi Maekawa et al. 2013; This article is distributed the terms of Creative Commons attribution 3.0 License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.)