Case Series


Bleeding and malignant pancreatic neuroendocrine neoplasms: A Malaysian case series

,  ,  ,  ,  

1 Medical Officer, Hepatobiliary Surgery, Sarawak General Hospital, Kuching, Sarawak, Malaysia

2 Hepatobiliary Surgeon, Hepatobiliary Surgery, Sarawak General Hospital, Kuching, Sarawak, Malaysia

3 Consultant Hepatobiliary Surgeon, Hepatobiliary Surgery, Sarawak General Hospital, Kuching, Sarawak, Malaysia

4 Senior Consultant Hepatobiliary Surgeon, Hepatobiliary Surgery, Sarawak General Hospital, Kuching, Sarawak, Malaysia

Address correspondence to:

Muthu Viknesh

V304, MJC Courtyard Sanctuary, Batu Kawah New Township, Jalan Batu Kawa 93250, Kuching, Sarawak,

Malaysia

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Article ID: 100084Z04MV2019

doi: 10.5348/100084Z04MV2019CS

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How to cite this article

Viknesh M, Hisham FB, Sankaran P, Choon SK, Abdullah NABN. Bleeding and malignant pancreatic neuroendocrine neoplasms: A Malaysian case series. Int J Hepatobiliary Pancreat Dis 2019;9:100084Z04MV2019.

ABSTRACT


Introduction: Pancreatic neuroendocrine neoplasm (PNEN) is a rare malignancy arising from the endocrine tissue of the pancreas. These tumors are classified based on functional (hormonal) status and malignant potential. Symptoms and signs are related to the hormonal function, tumor size, and metastatic effect. The majority are sporadic, non-functioning while insulinoma remains the most prevalent functional variety of these tumors.

Case Series: We present two cases of PNEN with different presentations and treatments; one with a resectable disease who presented as a rare case of bleeding PNEN, and the other who was unresectable due to extensive metastatic PNEN.

Conclusion: Pancreatic neuroendocrine neoplasm is a heterogeneous group of disorder with a multitude of clinical presentation. Each patient must be investigated and managed appropriately according to the treatment of choice. In keeping with the purpose of this article, we suggest a bleeding PNEN, a rare occurrence, is best managed with surgery, while unresectable metastatic PNEN would benefit from appropriate medical therapy.

Keywords: Metastasis, Pancreas, Pancreatic neuroendocrine neoplasm, Surgery

SUPPORTING INFORMATION


Author Contributions

Muthu Viknesh - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published

Faqihuddin Bin Hisham - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published

Padmaan Sankaran - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published

Soon Kong Choon - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published

Nik Azim Bin Nik Abdullah - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published

Guarantor of Submission

The corresponding author is the guarantor of submission.

Source of Support

None

Consent Statement

Written informed consent was obtained from the patient for publication of this article.

Data Availability

All relevant data are within the paper and its Supporting Information files.

Conflict of Interest

Authors declare no conflict of interest.

Copyright

© 2019 Muthu Viknesh et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.