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Original Article
 
Expression of Her2/neu receptor in carcinoma gallbladder correlates significantly with advanced tumor stage
Farzana Ashai1, Aadil Ashraf2, Arshad Rashid3, Bilal Musharaf Banday2, Sunita Bhalla4, Shashi Dhawan4
1Senior Resident, Department of Pathology, Sheri Kashmir Institute of Medical Science Medical College, Srinagar – 190015; Post Graduate Scholar, Department of Pathology, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi – 110060, India
2Senior Resident, Department of Pathology, Government Medical College, Srinagar – 190010
3Medical Officer, ASYM District Hospital, Budgam, Health Services Kashmir – 190014.
4Senior Consultant, Department of Pathology, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi – 110060, India.

Article ID: 100040IJHPDFA2015
doi:10.5348/ijhpd-2015-40-CR-15

Address correspondence to:
Dr. Arshad Rashid
G – 22, Shah Anwar Colony
Hyderpora, Srinagar
(INDIA) - 190014
Phone: +918494095736

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How to cite this article
Ashai F, Ashraf A, Rashid A, Banday BM, Bhalla S, Dhawan S. Expression of Her2/neu receptor in carcinoma gallbladder correlates significantly with advanced tumor stage. Int J Hepatobiliary Pancreat Dis 2015;5:86–91.


Abstract
Aims: Overexpression of Her2/neu is associated with increased disease recurrence and worse prognosis in many cancers. The aim of this study was to correlate Her2/neu positivity with the histopathological features in carcinoma gallbladder.
Methods: This study was conducted on 54 cholecystectomy specimens of carcinoma gallbladder in a superspecialty referral center from January 2007 to July 2011. A gross evaluation of tumor, study of histopathology and immunohistochemical staining was done for Her2/neu. The relative frequency of Her2/neu positivity was scored and correlated with other histological prognostic parameters of the tumor.
Conclusion: Maximum cases in our study were in stage T2 at the time of diagnosis and most of them were moderately differentiated carcinoma. Her2/neu was strongly positive in five cases (9.25%) of gallbladder cancer and 14 cases (25.92%) showed moderate positivity. There was a lot of heterogeneity in the expression of Her2/neu showing 1+ and 2+ positivity in different areas. No correlation was seen between immunohistochemical staining pattern and tumor grade, but frequency of Her2/neu positive cases was highest in advanced stage (p = 0.042).
Conclusion: Her2/neu expression occurs in gallbladder cancer, especially in advanced stage disease and its therapeutic targeting seems promising.

Keywords: Expression, Gallbladder cancer, Her2/neu, Histopathology, Prognosis

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Author Contributions:
Farzana Ashai – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Aadil Ashraf – Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Arshad Rashid – Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Bilal Musharaf Banday – Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Sunita Bhalla – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Shashi Dhawan – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2015 Farzana Ashai et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.