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Original Article
 
Reduction of peritoneal adhesion bands by mycophenolate mofetil (CellCept) and prednisolone in rats
Behnam Sanei1, Mohsen Mahmoudieh1, Parnian Shariati2, Ehsan Zare Bidaki3, Hamid Talebzade2, Hamid Reza Jafari4
1Assistant Professor, Department of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran.
2Department of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran.
3Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
4Medical Student, Isfahan University of Medical Sciences, Isfahan, Iran.

Article ID: 100019IJHPDGN2014
doi:10.5348/ijhpd-2014-19-OA-7

Address correspondence to:
Dr. Parnian Shariati
Department of Surgery, Isfahan University of Medical Sciences
Isfahan
Iran
Email: p.shariati2000@gmail.com

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How to cite this article
Sanei B, Mahmoudieh M, Shariati P, Bidaki EZ, Talebzade H, Jafari HR. Reduction of peritoneal adhesion bands by mycophenolate mofetil (CellCept) and prednisolone in rats. Int J Hepatobiliary Pancreat Dis 2014;4:39–44.


Abstract
Aims: The purpose of this study was to assess the efficacy of prednisolone and CellCept in decreasing postoperative adhesion band formation in rats.
Methods: Sixty male rats were randomly divided into three equal groups. A standard midline incision was made on the abdomen of each rat, then 2 mL of 10% sterile solution Talc was injected into intraperitoneal cavity in order to induce adhesion. Group 1 served as control group, while group 2 received oral CellCept (40 mg/kg/d) and group 3 received oral Prednisolone (5 mg/kg/d) for 4 weeks.
Results: The formation of adhesion bands in control group was significantly higher than the prednisolone and CellCept group (p <0.001). The amount of adhesion bands in the second group was similar to the third one.
Conclusion: Orally administered CellCept is as effective as oral prednisolone in declining chance of intraperitoneal adhesion band formation, although it causes fewer complications such as infection in rats.

Keywords: Adhesion band, Mycophenolate Mofetil (CellCept), Prednisolone

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Author Contributions:
Behnam Sanei – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Mohsen Mahmoudieh – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Parnian Shariati – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Ehsan Zare Bidaki – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Hamid Talebzade – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Hamid Reza Jafari – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2014 Behnam Sanei et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.