Table of Contents    
Original Article
 
Clinical evaluation on the determination of plasma lysophosphatidic acid concentration in Chinese human pancreatic cancer
Gong - Yongling1, Wang - Shaokai1, Tao - Chenjie1, Chen - Jinfei1, Wang - Shukui2, Cao - Xiufeng1, Lv - Guangmei3, Li - Pin4
1Department of Oncology, Nanjing 1st Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China.
2Department of Central Lab, Nanjing 1st Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China.
3Department of Medicine and Nursing Education, Proffessional College of Jiangsu Jiankang, Nanjing 210029, China.
4Department of Gastroenterology, Changhai Hospital, Shanghai 200433, China.

Article ID: 100002IJHPDGY2011
doi:10.54348/ijhpd-2011-2-OA-2

Address correspondence to:
Li Pin, MD
Department of Gastroenterology
Changhai Hospital
Shanghai 200433, P.R.
China
Fax: +86-25-84800605
Email: pinli1965@163.com

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How to cite this article:
Yongling G, Shaokai W, Chenjie T, Jinfei C, Shukui W, Xiufeng C, Guangmei L, Pin L. Clinical evaluation on the determination of plasma lysophosphatidic acid concentration in Chinese human pancreatic cancer. International Journal of Hepatobiliary and Pancreatic Diseases 2011;1:6-12.


Abstract
Aims: Observing the alteration of plasma Lysophosphatidic acid (LPA) concentration in patients with pancreatic cancer and evaluating its clinical potential for diagnosis.
Methods: We examined the plasma LPA concentrations by using a LPA assay kit and related parameters of CA19-9, AFP and CEA were measured in 50 patients with pancreatic cancer, 32 patients with benign pancreatic lesions and 36 healthy check-up volunteers. Findings were analyzed and correlation with pathological changes.
Results: The LPA concentration was significantly higher in pancreatic cancer patients (4.10±2.03 µmol/L) than in patients with benign lesions (3.28±1.26 µmol/L) and healthy controls (2.27±1.02 µmol/L) (p < 0.05). Plasma LPA concentration correlated with serum CA19-9 level (r = 0.9070) in patients with pancreatic cancer. For diagnosis of pancreatic cancer, the sensitivity of LPA was 89.6% and the specificity 79. 4%, while the sensitivity of CA19-9 was 91.8% and specificity 84.8%. Statistical analysis showed no difference between the plasma LPA concentration and serum CA19-9 activity. However, alteration of plasma LPA has shown significant correlations with the tumor size, pathological classification, pathological stage, infiltration of capsule cells, surrounding lymph nodes and specific histopathological features.
Conclusions: LPA might provide clinical physicians with aditional indicator of diagnosis, metastasis and prognosis, making it a promising biomarker for pancreatic cancer. Our findings suggested that LPA would be a potential target for treatment of pancreatic cancers.

Key Words: Lysophosphatidic acid; CA19-9; Pancreatic cancer; Cancer diagnosis

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Author Contributions:
Gong Yongling - Substantial contributions to conception and design, acquisition of data, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published
Wang Shaokai - Substantial contributions to conception and design, analysis and interpretation of data, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published
Tao Chenjie - Substantial contributions to conception and design, analysis and interpretation of data, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published
Chen Jinfei - Substantial contributions to conception and design, analysis and interpretation of data, Drafting the article, Final approval of the version to be published
Wang Shukui - Substantial contributions to conception and design, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published
Cao Xiufeng - Substantial contributions to conception and design, analysis and interpretation of data, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published
Lv Guangmei - Substantial contributions to conception and design, analysis and interpretation of data, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published
Li Pin - Substantial contributions to conception and design, analysis and interpretation of data, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission:
The corresponding author is the guarantor of Submission.
Source of support:
None
Conflict of interest:
The authors declare no conflict of interest.
Copyright:
© Gong Yongling et al. 2011; This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.)